Tehran University of Medical Sciences Journal of Biostatistics and Epidemiology 2383-4196 1 1/2 2015 10 19 37 44 EN Zahra Nikooseresht Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Shahnaz Rimaz Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mohsen Asadi-Lari Department of Epidemiology & Biostatistics, School of Public Health, Oncopathology Research Centre, Tehran University of Medical Sciences, Tehran, Iran Saharnaz Nedjat Department of Epidemiology & Biostatistics, School of Public Health, Knowledge Utilization Research Center, Tehran University of Medical Sciences, Tehran, Iran Effat Merghati-Khoee Iranian National Center of Addiction Studies (INCAS), Institution of Risk Reduction, Tehran, Iran AND Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina (MUSC), USA Nargess Saiepour Department of Epidemiology & Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran AND School of Public Health, University of Queensland, Queensland, Australia 2015 10 13 2015 10 13 Background & Aim: Quality-of-life (QOL) among human immunodeficiency  virus (HIV)-infected people  has been  the center  of  focus  worldwide.  The World  Health  Organization  QOL  Group (WHOQOL  Group)  has developed  a 31-item QOL questionnaire,  which  has been  translated  and used in many countries. This paper aimed at examining the reliability and validity of Persian version of HIV specific WHOQOL  scaleBREF questionnaire  (WHOQOL-HIV BREF) in Iranian patients suffering from HIV/acquired immunodeficiency syndrome (AIDS). Methods  &  Materials:  For  the  purpose  of  this  cross-sectional   study,  a  standard  “ forward- backward” translation  and  cognitive  debriefing  were initially  applied.  Subsequently,  150 people living with HIV/AIDS visitingTertiary Referral Consultation Center for clients with risky behaviors in Tehran completed the Persian version of the questionnaire. Validity was assessed using   Known Group Comparison  through ANOVA test. Internal reliability was measured by Cronbach 's  alpha and Split-Half coefficients. Results:  WHOQOL-HIV   BREF  was  capable  to  discriminate  between  two groups  who  were different  in  their  QOL (P<  0.05).  Internal  consistency analysis  was  satisfactory  for  domains (Cronbach’s alpha =0.64- 0.85), and whole the instrument (Cronbach's alpha=0.93). Conclusion:  The Persian version of WHOQOL-HIV  BREF is a reliable and valid instrument  to assess the QOL among Iranian HIV-infected population. https://jbe.tums.ac.ir/index.php/jbe/article/view/14 https://jbe.tums.ac.ir/index.php/jbe/article/download/14/22