Tehran University of Medical Sciences Journal of Biostatistics and Epidemiology 2383-4196 11 2 2025 06 15 214 229 EN Ilir Akshija Tirana Univeristy Hospital Center 2025 01 09 2025 09 15 Backgrounds Epidemiological hospital data on primary brain cancers and mental illnesses can support research showing that epigenetic aberrations, among others, can be common for both entities. Methods Retrospective data from Electronic Patients Records (EPR) from TUHC “Mother Teresa”, Albania, years 2005-2021, were analyzed after creating cutoffs on age, county (capital), epilepsy diagnosis, first admission and diagnosis groups. Combination of age at first hospitalization for the two groups of diagnoses was tested for normality, hypothesized to be a composed normal distribution. Results The total number of patients fulfilling selection criteria for the period 2005-2021, was 48,303 admissions. First admissions were N=31,603 (65.4%), of which N=15,896 (50.3%) were from Tirana (the capital) county. The number of first admissions for the two major categories for Tirana (the capital) county were respectively; 6,807 (42.8%) and 9,089 (57.2%). Age on first admission mean (median) for Tirana county was 35.1 ± 22.1 (36.0) years. Age on first admission, mean (median), for the two major categories ‘Mental Disorders’ and ‘Other’ for Tirana county were respectively; 37.7 ± 15.4 (37.2) years and 33.0 ± 26.3 (31.0) years and split by sex; male (36.2 ± 15.4 (35.3) years and 32.4 ± 26.4 (28.0) years, p<0.001) and female (39.4 ± 15.4 (39.6) years and 33.8 ± 33.0 (26.0) years, p<0.019). Age-specific distribution (> 15years) data on ‘Mental Disorders’, ‘Other’ and ‘Total’ for Tirana county test positive about normality, Shapiro-Wilk > 0.005 but the only the data for ‘mental disorders’ don’t pass the ‘‘95% range check’’. Conclusions Independent or common causative factors of Primary Malignant Neoplasm of Brain (PMNB) and Serious Mental Illness (SMI) show patterns of continuity at the age of first hospitalization. https://jbe.tums.ac.ir/index.php/jbe/article/view/1567