Tehran University of Medical Sciences Journal of Biostatistics and Epidemiology 2383-4196 4 4 2019 03 13 196 202 Masoud Mirzaei Department of Cardiology, Yazd Cardiovascular Research Centre, Faculty of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran Hossein Lashkardoost Department of Public Health, School of Public Health, North Khorasan University of Medical Sciences, Bojnurd, Iran Andishe Hamedi Department of nursing, Shirvan Center of Higher Health Education, North Khorasan University of Medical Sciences, Bojnurd, Iran 2018 11 11 Background & Aim: Today, quality of life has attracted more attention and there is a relationship between disease and quality of life. This study was conducted to evaluate the quality of life in diabetics and nondiabetics and other demographic variables related to the quality of life of individuals. Methods & Materials: This cross-sectional study was carried out on a random sample of 7533 subjects, using the Health Survey data in Yazd. For assessing the quality of life, SF8 questionnaire was used. Data were analyzed by using, t-test and linear regression model in SPSS19.  Results: There were, significantly different between quality of life in diabetics and non-diabetics individual, and this relationship can be generalized to the subscales of quality of life(P<0.001).  It has shown that becoming old, being female and being single were associated with decreasing quality of life, and increasing the level of education and having assurance had a significant role in improving the quality of life(p<0.05). Conclusion: Since diabetic patient had lower quality of life than non-diabetics. It is suggested, to promote the quality of life of patients, health authorities should plan the solutions for supporting and promoting patients with diabetes` health. https://jbe.tums.ac.ir/index.php/jbe/article/view/222 https://jbe.tums.ac.ir/index.php/jbe/article/download/222/176