Tehran University of Medical Sciences Journal of Biostatistics and Epidemiology 2383-4196 8 1 2022 03 15 90 101 Tayebeh Rakhshani Nutrition Research Center, Department of Public Healt, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran Hamid Salehiniya Social Determinants of Health Research Center, Birjand University of Medical Sciences, Birjand, Iran Monire Azizi Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran Alireza Ansari-moghadam Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. seydeh Zeinab Almasi Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. AND Department of Epidemiology and Biostatistics, Tehran University of Medical Sciences, Tehran, Iran. Hassan okati Aliabad Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran 2021 08 28 2021 10 23 Background: recent medical and health advances have reduced mortality, consequently a relative increase in life expectancy and aging of population. One of the indices that properly indicate the status of elderly is the quality of life index. Objectives: objective of the present study was to identify the factors affecting the quality of life of the elderly in Zahedan, Iran. Methods: This cross-sectional study was performed on 600 elderly people referring to the Zahedan health centers. In this two-stage cluster random sampling method, the data were collected in the  check list  and  the quality of life questionnaire SF12 through interview and  analyzed using independent t-test, one-way ANOVA, Pearson correlation coefficient and  multiple linear regression Results: Of the 600 elderly men and women over 60 years, 472 subjects participated in the study, of whom 291 (61%) were male and 182 (39%) female. The mean age of the study subjects was 66.2(4.04), and the mean overall quality of life scores in males and females were 28.4(3.7) and 29.07(3.7), respectively. The mean and standard deviation of PCS and MCS scores in males and females were 12.3(2.2) and 16.6(2.5), respectively. Age had inverse correlation with QOL and MS and had a direct and significant relationship with PCS. In multiple linear regression, significant relation was observed between chronic illness, hypertension, skeletal disease, diabetes, gastrointestinal disease, marital status, hookah use and smoking with PCS and also between marital status, Hypertension and mental illness with MCS. Conclusions: What is obtained from this study and the other relevant studies indicate that QOL is a multifactorial phenomenon that is influenced by demographic, clinical and behavioral factors, but the role of chronic diseases is more obvious. Therefore, it seems necessary to adopt health policies to correct the lifestyle of society   https://jbe.tums.ac.ir/index.php/jbe/article/view/708 https://jbe.tums.ac.ir/index.php/jbe/article/download/708/359