Tehran University of Medical Sciences Journal of Biostatistics and Epidemiology 2383-4196 8 4 2022 12 15 The Coagulopathy-Predicting Factors In Acute Trauma Patients Using The Generalized Estimation Equations Model 372 378 Zahra Montazeri M.SC Biostatistics.Shahrekourd university medical Science Soleiman Kheiri 0000-0001-8285-8681 Shahram Paydar 0000-0002-6980-2576 Morteza Sedehi 0000-0002-6980-2576 2022 01 22 2023 02 21 Introduction: Coagulation disorder is one of the major phenomena following the trauma which can deteriorate the condition of the patients. The aim of this study is to determine some factors predicting the incidence of coagulation disorder among acute trauma patients. Methods: The generalized estimation equations were used to determine the predictors of blood coagulation disorders in a sample of 736 people over 16 years of age with acute trauma in Shahid Rajaei Hospital in Shiraz. The response variable was converted based on PT, PTT, INR, and fibrinogen level criteria as a two-state variable (with/without coagulation disorder). In the data analysis, the correlation of the coagulation disorder was considered in the first and second stages. Results:The prevalence of coagulation disorders (mild, moderate and severe) was 19% in two stages and coagulation disorders (moderate and severe) was 7.5%. Motor vehicle accident was the most common cause of injury.The variables of blood sugar, diastolic blood pressure, pH, and sodium had a significant effect on coagulation disorders (mild, moderate, and severe). Moreover, blood phosphorus, age, and pupillary reflex had a significant effect on coagulation disorders (moderate and severe). Conclusion: Predictors of coagulation disorders (mild-moderate-severe) include blood sugar, diastolic blood pressure, pH, and sodium. Moreover, blood phosphorus, age, and pupil reflex are predictors of moderate and severe coagulopathy. this model that taking into account the exchangeable correlation of first- and second-stage coagulopathy had a better fit than the model ignoring this correlation. https://jbe.tums.ac.ir/index.php/jbe/article/view/850 https://jbe.tums.ac.ir/index.php/jbe/article/download/850/420