Journal of Biostatistics and Epidemiology 2016. 2(2):52-59.

Cure mixture model based on hazard modeling non-proportional, application to esophageal cancer
Mahboubeh Rasouli, Mahmoodreza Ghadimi, Masoomeh Shohani, Asieh Ashouri, Samaneh Hosseinzadeh, Kazem Mohammad, Mahmood Mahmoodi

Abstract


Background & Aim: Esophageal cancer is one of the main common causes of death. The high prevalence of esophageal cancer in northern Iran is an important public health problem. The main aim of this paper was to assess the factors affecting survival of  atients with esophageal cancer in neighbor provinces around the Caspian Sea using Weibull mixture cure model and mixture cure model based on a non-proportional hazard.
Methods & Materials: This prospective study was designed to gather data of esophageal cancer from the Babol cancer registry, Iran, registered during 1990 to 1991. The study cases were also followed for a period of 15 years up to 2006. Mixture cure model via non-proportional hazard modeling was used to calculate cure fraction and investigate the factors responsible for the cure probability of patients. Estimates were obtained by maximization of the likelihood via SAS proc NLMIXED.
Results: The median survival time was about 9 months and survival probability in 1, 3, and 5 years following diagnosis were 23%, 15% and 13%, respectively. The family history affected the cured fraction independently of its effect on the early outcome  In addition, it had significant effect on the probability of uncured state in the both models.
Conclusion: The results demonstrated the great potential in cure modeling survival data via nonproportional hazard model compared to Weibull mixture cure model.


Keywords


Long-term survival; Esophageal cancer; Non-Proportional hazard model; Mixture cure model

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