Using Bayesian networks model predicting pregnancy after psychiatric interventions in infertile couple
Abstract
Background & Aim: Considering the psychosocial model of diseases, the aim of this study was to evaluate the effect of psychiatric intervention with regard to demographic and marriage characteristics on the pregnancy rate using Bayesian network model in infertile women.
Methods & Materials: In a randomized clinical trial, 638 infertile patients
referred to an infertility clinic were evaluated. Among them, 140 couples with different levels of depression in at least one of the spouses were included in this substudy. These couples were divided randomly into two groups. After psychiatric intervention the clinical pregnancy rates of the two groups. The data were divided into two groups: demographic characteristics and marriage specifications, and by drawing Bayesian networks using Grow-Shrink (GS) algorithm, the conditional probability of pregnancy was estimated.
Results: According to the results, Bayesian network model of the GS algorithm was significant (P = 0.548) and given that the fertility in the intervention group who were concurrently treated with antiretroviral treatment, the conditional probability was 38.5%, and this amount in the control group is 3.5% and group who were concurrently treated with induction of ovulation or did not receive any treatment the conditional probability was 72.2% and this amount in the control group is 23.1% comparing the values shows the importance of psychiatric intervention in increasing pregnancy rate.
Conclusion: Results obtained from Bayesian network model are in line with results obtained from logistic model in terms of the significance of the variables with the difference that apart from the graphic structure, Bayesian network model also estimates conditional probabilities. This study shows that psychiatric and psychological treatments play an important role in curing infertility that will increase the chances of pregnancy.
Ramezanzadeh F, Noorbala AA, Malak Afzali H, Abedinia N, Rahimi A, Shariet M, et al. Effectiveness of psychiatric and counseling interventions on fertility rate in infertile couples. Tehran Univ Med J 2007; 65(8): 57-63. (In Persian).
Margaritis D. Learning Bayesian network model structure from data (PhD Thesis). Pittsburgh, PA: Carnegie Mellon University; 2003. 3. Neapolitan RE. Learning Bayesian networks. Upper Saddle River, NJ: Prentice-Hall, Inc; 2003.
Niloofar P, Ganjali M. Assessing effective factors on poverty using Bayesian networks. Social Welfare 2008; 7(28): 107-28. (In Persian).
Geiger D, Verma TS, Pearl J. d-Separation: From theorems to algorithms. Proceedings of the 5th Annual Conference on Uncertainty in Artificial Intelligence; 1989 Aug 18-20; Windsor, ON, Canada.
Nielsen TD, Jensen FV. Bayesian networks and decision graphs. 2nd ed. New York, NY: Springer; 2007.
Scutari M. Learning Bayesian networks with the bnlearn R package. J Stat Softw 2010; 1(3); 1-22.
Koski T, Noble J. Bayesian networks: An introduction. Hoboken, NJ: John Wiley and Sons; 2011.
Pellet JP, Elisseeff A. Using Markov blankets for causal structure learning. J Mach Learn Res 2008; 9: 1295-342.
Fienberg SE. Log-linear models in contingency tables. Hoboken, NJ: John Wiley and Sons; 2006.
Cwikel J, Gidron Y, Sheiner E. Psychological interactions with infertility among women. Eur J Obstet Gynecol Reprod Biol 2004; 117(2): 126-31.
Lovely LP, Meyer WR, Ekstrom RD, Golden RN. Effect of stress on pregnancy outcome among women undergoing assisted reproduction procedures. South Med J 2003; 96(6): 548-51.
Bringhenti F, Martinelli F, Ardenti R, La Sala GB. Psychological adjustment of infertile women entering IVF treatment: differentiating aspects and influencing factors. Acta Obstet Gynecol Scand 1997; 76(5): 431-7.
Facchinetti F, Tarabusi M, Volpe A. Cognitive-behavioral treatment decreases cardiovascular and neuroendocrine reaction to stress in women waiting for assisted reproduction. Psychoneuroendocrinology 2004; 29(2): 162-73.
Tarabusi M, Volpe A, Facchinetti F. Psychological group support attenuates distress of waiting in couples scheduled for assisted reproduction. J Psychosom Obstet Gynaecol 2004; 25(3-4): 273-9. 16. Boivin J. A review of psychosocial interventions in infertility. Soc Sci Med 2003; 57(12): 2325-41.
McNaughton-Cassill ME, Bostwick JM, Arthur NJ, Robinson RD, Neal GS. Efficacy of brief couples support groups developed to manage the stress of in vitro fertilization treatment. Mayo Clin Proc 2002; 77(10): 1060-6.
Yong P, Martin C, Thong J. A comparison of psychological functioning in women at different stages of in vitro fertilization treatment using the mean affect adjective check list. J Assist Reprod Genet 2000; 17(10): 553-6.
Morales DA, Bengoetxea E, Larranaga P. Selection of human embryos for transfer by Bayesian classifiers. Comput Biol Med 2008; 38(11-12): 1177-86.
Corani G, Magli C, Giusti A, Gianaroli L, Gambardella LM. A Bayesian network model for predicting pregnancy after in vitro fertilization. Comput Biol Med 2013; 43(11): 1783-92.
Kim IC, Jung YG. Using Bayesian networks to analyze medical data. In: Perner P, Rosenfeld A, Editors. Machine learning and data mining in pattern recognition: Third International Conference, MLDM 2003 Leipzig, Germany, July 5-7, 2003 Proceedings. Berlin, Heidelberg: Springer Berlin Heidelberg; 2003. p. 317-27.
Bozkurt S, Uyar A, Gulkesen KH. Comparison of Bayesian network and binary logistic regression methods for prediction of prostate cancer. Proceedings of the 14th International Conference on Biomedical Engineering and Informatics; 2011 Oct 1517; Shanghai, China.
Files | ||
Issue | Vol 2 No 4 (2016) | |
Section | Original Article(s) | |
Keywords | ||
Bayesian networks model Psychiatric interventions Infertility Predicting pregnancy Markov blanket Grow-Shrink algorithm |
Rights and permissions | |
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. |