Case-crossover and case-time-control studies: concepts, design, and analysis
Abstract
Background & Aim: Case-crossover studies are the case-control version of crossover studies. In these studies, cases and controls are the same subjects. The term crossover is applied for designs that all subjects pass through both treatment (exposure) and placebo (non-exposure) phases. In fact they are crossover of subjects between periods of exposure and non-exposure. This design is most suitable for outcomes, which their induction time is short. Whatever the onset of outcome is more abrupt, it is more amenable to be studied in case-crossover studies. Case-crossover design can be implemented in a number of ways. In this article some common terms in the literature of casecrossover studies, major concerns in selection of controls, different ways for designing casecrossover studies, some examples for analyzing these data according to different sampling designs and also design and analysis of case-time-control designs with practical examples are being explored.
Maclure M. The case-crossover design: a method for studying transient effects on the risk of acute events. Am J Epidemiol 1991;133(2): 144-53.
Maclure M, Mittleman MA. Should we use a case-crossover design? Annu Rev Public Health 2000; 21: 193-221.
Maclure M, Mittleman MA. Cautions about car telephones and collisions. N Engl J Med
; 336(7): 501-2.
Mittleman MA, Maclure M, Sherwood JB, Mulry RP, Tofler GH, Jacobs SC, et al. Triggering of acute myocardial infarction onset by episodes of anger. Determinants of Myocardial Infarction Onset Study Investigators. Circulation 1995; 92(7): 1720-5.
Rothman KJ, Greenland S, Lash TL. Modern Epidemiology. Philadelphia, PA: Lippincott
Williams & Wilkins; 2008.
Dixon KE. A comparison of case-crossover and case-control designs in a study of risk factors for hemorrhagic fever with renal syndrome. Epidemiology 1997; 8(3): 243-6.
Redelmeier DA, Tibshirani RJ. Association between cellular-telephone calls and motor vehicle collisions. N Engl J Med 1997;336(7): 453-8.
Willich SN, Lewis M, Lowel H, Arntz HR, Schubert F, Schroder R. Physical exertion as a trigger of acute myocardial infarction. Triggers and Mechanisms of Myocardial Infarction Study Group. N Engl J Med 1993;329(23): 1684-90.
Gullette EC, Blumenthal JA, Babyak M, Jiang W, Waugh RA, Frid DJ, et al. Effects of mental stress on myocardial ischemia during daily life. JAMA 1997; 277(19):1521-6.
Hallqvist J, Moller J, Ahlbom A, Diderichsen F, Reuterwall C, de Faire U. Does heavy physical exertion trigger myocardial infarction? A case-crossover analysis nested in a population-based case- referent study. Am J Epidemiol 2000;151(5): 459-67.
Marshall RJ, Jackson RT. Analysis of case- crossover designs. Stat Med 1993; 12(24):2333-41.
Petridou E, Mittleman MA, Trohanis D, Dessypris N, Karpathios T, Trichopoulos D. Transient exposures and the risk of childhood injury: a case-crossover study in Greece. Epidemiology 1998; 9(6): 622-5.
Navidi W. Bidirectional case-crossover designs for exposures with time trends. Biometrics 1998; 54(2): 596-605.
Breslow NE, Day NE. Statistical methods in cancer research: Vol. 1: The analysis of case-control studies. Lyon, France: International Agency for Research on Cancer; 1980.
Mittleman MA, Maclure M, Robins JM.Control sampling strategies for case- crossover studies: an assessment of relative efficiency. Am J Epidemiol 1995; 142(1):91-8.
Greenland S, Robins JM. stimation of a common effect parameter from sparse follow- up data. Biometrics 1985; 41(1): 55-68.
Hernandez-Diaz S, Hernan MA, Meyer K, Werler MM, Mitchell AA. Case-crossover and case-time-control designs in birth defects epidemiology. Am J Epidemiol 2003; 158(4): 385-91.
Suissa S. The case-time-control design. Epidemiology 1995; 6(3): 248-53.
Suissa S. The case-time-control design:further assumptions and conditions.Epidemiology 1998; 9(4): 441-5.
Schneeweiss S, Sturmer T, Maclure M. Case- crossover and case-time-control designs as alternatives in pharmacoepidemiologic research. Pharmacoepidemiol Drug Saf 1997; 6(Suppl 3): S51-S59.
Greenland S. Confounding and exposure trends in case-crossover and case-time- control designs. Epidemiology 1996; 7(3):231-9.
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| Issue | Vol 1 No 1/2 (2015) | |
| Section | Methodology | |
| Keywords | ||
| case-crossover case-time-control design and analysis | ||
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