Original Article

Screening of hypercalciuria among children with persistent asymptomatic hematuria

Abstract

Background & Aim: Hypercalciuria is commonly observed in accompany with some conditions. Hypercalciuria can clinically present different symptoms and signs. The diagnostic methods for hypercalciuria have not yet been standardized. The presented study was accomplished with the aim to assess whether random urinary calcium/creatinine ratio (UCa/Cr) could be used as a screening tool for hypercalciuria among children with persistent asymptomatic hematuria.
Methods & Materials: This cross-sectional study included 100 children with primary hematuria for whom both random and 24-hour urinary evaluations were performed. Pearson correlation coefficient (PCC) was used to assess the correlations.
Results: There was a moderate correlation between random UCa/Cr and 24-hour urinary calcium excretion (UCaE) (r = 0.511, P < 0.001). Body mass index (BMI) and 24-hour UCaE affected random UCa/Cr (r2 = 0.385, P < 0.001).
Conclusion: 24-hour urinary analysis is preferred to random UCa/Cr. Random UCa/Cr is not appropriate for screening hypercalciuria among children with persistent asymptomatic hematuria.

van der Watt G, Omar F, Brink A, McCulloch M. Laboratory investigation of the child with suspected renal disease. In: Avner ED, Harmon WE, Niaudet P, Yoshikawa N, Emma F, Goldstein S, Editors. Pediatric Nephrology. 7th ed. Berlin, Germany: Springer Berlin Heidelberg; 2016. p. 626.

Sepahi MA, Heidari A, Shajari A. Clinical manifestations and etiology of renal stones in children less than 14 years age. Saudi J Kidney Dis Transpl 2010; 21(1): 181-4.

Craig C, Avner ED. Idiopathic Hypercalciuria. In: Kliegman RM, Stanton B, Editors. Nelson Textbook of Pediatrics. Philadelphia, PA: Elsevier Health Sciences; 2016. p. 2511.

Akhavan-Sepahi M, Sharifian M, Mohkam M, Vafadar M, Hejazi S. Biochemical risk factors for stone formation in healthy school children. Acta Med Iran 2012; 50(12): 814-8.

Arrabal-Polo MA, Arias-Santiago S, Giron-Prieto MS, Abad-Menor F, Lopez-Carmona PF, Zuluaga-Gomez A, et al. Hypercalciuria, hyperoxaluria, and hypocitraturia screening from random urine samples in patients with calcium lithiasis. Urol Res 2012; 40(5): 511-5.

Hong YH, Dublin N, Razack AH, Mohd MA, Husain R. Twenty-four hour and spot urine metabolic evaluations: Correlations versus agreements. Urology 2010; 75(6): 1294-8.

Choi IS, Jung ES, Choi YE, Cho YK, Yang EM, Kim CJ. Random urinary calcium/creatinine ratio for screening hypercalciuria in children with hematuria. Ann Lab Med 2013; 33(6): 401-5.

Vijayakumar M, Nageswaran P, Tirukalathi OM, Sudha E, Priyadarshini S. Descriptive study of clinical profile and benefit of therapy in childhood hypercalciuria. Int J Nephrol Renovasc Dis 2014; 7: 69-73.

Balestracci A, Meni BL, Toledo I, Martin SM, Wainsztein RE. Idiopathic hypercalciuria in children with urinary tract infection. Arch Argent Pediatr 2014; 112(5): 428-33.

Ryan LE, Ing SW. Idiopathic hypercalciuria: Can we prevent stones and protect bones? Cleve Clin J Med 2018; 85(1): 47-54.

Wagner CA, Rubio-Aliaga I, Hernando N. Renal phosphate handling and inherited disorders of phosphate reabsorption: an update. Pediatr Nephrol 2017.12. Koratala A, Bhatti V. Medullary nephrocalcinosis in idiopathic hypercalciuria. Clin Case Rep 2017; 5(11): 1903-4.

Esteghamati M, Ghasemi K, Nami M. Prevalence of idiopathic hypercalciuria in children with urinary system related symptoms attending a pediatric hospital in Bandar Abbas in 2014. Electron Physician 2017; 9(9): 5261-4.

Assadi F, Moghtaderi M. Preventive kidney stones: Continue medical education. Int J Prev Med 2017; 8: 67.

Lee JH, Choi HW, Lee YJ, Park YS. Causes and outcomes of asymptomatic gross haematuria in children. Nephrology (Carlton) 2014; 19(2): 101-6.

Moghtaderi M, Noohi AH, Safaeyan B, Abbasi A, Sabsechian M, Meherkash M. Screening for microscopic hematuria in school-age children of Gorgan City. Iran J Kidney Dis 2014; 8(1): 70-2.

Praga M, Alegre R, Hernandez E, Morales E, Dominguez-Gil B, Carreno A, et al. Familial microscopic hematuria caused by hypercalciuria and hyperuricosuria. Am J Kidney Dis 2000; 35(1): 141-5.

Spivacow FR, Del Valle EE, Rey PG. Metabolic risk factors in children with asymptomatic hematuria. Pediatr Nephrol 2016; 31(7): 1101-6.

Feld LG, Waz WR, Perez LM, Joseph DB. Hematuria. An integrated medical and surgical approach. Pediatr Clin North Am 1997; 44(5):1191-210.

Koyun M, Guven AG, Filiz S, Akman S, Akbas H, Baysal YE, et al. Screening for hypercalciuria in schoolchildren: What should be the criteria for diagnosis? Pediatr Nephrol 2007; 22(9): 1297-301.

Mir S, Serdaroglu E. Quantification of hypercalciuria with the urine calcium osmolality ratio in children. Pediatr Nephrol 2005; 20(11): 1562-5.

Reusz GS, Dobos M, Byrd D, Sallay P, Miltenyi M, Tulassay T. Urinary calcium and oxalate excretion in children. Pediatr Nephrol 1995; 9(1): 39-44.

Alconcher LF, Castro C, Quintana D, Abt N, Moran L, Gonzalez L, et al. Urinary calcium excretion in healthy school children. Pediatr Nephrol 1997; 11(2): 186-8.

Esbjorner E, Jones IL. Urinary calcium excretion in Swedish children. Acta Paediatr 1995; 84(2): 156-9.

Safarinejad MR. Urinary mineral excretion in healthy Iranian children. Pediatr Nephrol 2003; 18(2): 140-4.

Biyikli NK, Alpay H, Guran T. Hypercalciuria and recurrent urinary tract infections: Incidence and symptoms in children over 5 years of age. Pediatr Nephrol 2005; 20(10): 1435-8.

Stojanovic VD, Milosevic BO, Djapic MB, Bubalo JD. Idiopathic hypercalciuria associated with urinary tract infection in children. Pediatr Nephrol 2007; 22(9): 1291-5.

Files
IssueVol 3 No 3/4 (2017) QRcode
SectionOriginal Article(s)
Keywords
Hypercalciuria Hematuria Child Urinary tract Calcium Creatinine

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
How to Cite
1.
Akhavansepahi M, hoseini BL, Tabarai Y. Screening of hypercalciuria among children with persistent asymptomatic hematuria. JBE. 2018;3(3/4):106-110.